CAGRILINTIDE

Description

Cagrilintide is a long-acting synthetic analog of the natural hormone amylin, studied in published clinical research in combination with incretin analogues, and is also known as AM833 or NNC0174-0833.

A different mechanism from the incretins

Cagrilintide is frequently displayed alongside GLP-1 and GIP analogues, but it is not one. Amylin is a separate hormone, co-secreted with insulin from pancreatic beta cells, and it signals through amylin receptors and the calcitonin receptor rather than through incretin receptors. Cagrilintide is described as a non-selective agonist across both.

This distinction matters when designing comparative work. A study treating cagrilintide as interchangeable with an incretin analogue is comparing molecules that act on entirely different receptor families, which is also the reason the two classes are investigated in combination rather than as alternatives.

Structure

Native human amylin is itself 37 residues but is notoriously difficult to work with: it aggregates readily and forms amyloid fibrils, which is a significant obstacle both to formulation and to laboratory handling. Cagrilintide is engineered to address this.

The molecule carries an intramolecular disulfide bridge, reflecting the native hormone’s structure, and a C20 diacid lipid conjugation that binds serum albumin reversibly to extend circulating residence time. Substitutions relative to native amylin reduce the aggregation tendency that makes the parent hormone impractical.

Research background

Published work has characterised receptor binding and activation at amylin and calcitonin receptors in cell systems, and examined metabolic parameters in animal models. The compound has been the subject of human clinical investigation, including in combination with incretin analogues, on the rationale that the two receptor families act through independent routes.

No regulatory authority has approved cagrilintide. The material supplied here is for laboratory research only.

Storage and handling

Store the lyophilized powder at 36 to 46 °F (2 to 8 °C), desiccated and protected from light. Allow the vial to reach room temperature before opening.

Use 4409.01 g/mol for molar calculations.

Purity and verification

Each lot is analysed by an independent laboratory, with identity confirmed by mass spectrometry and purity by HPLC. Test scope varies by lot; consult the certificate for the lot you receive.

Compound Identity

CAS Number

1415456-99-3

Molecular Formula

C₁₉₄H₃₁₂N₅₄O₅₉S₂

Molecular Weight

4409.01 g/mol

Chain Length

37 amino acids, C-terminal amide

Modifications

C20 diacid lipid acylation; intramolecular disulfide bridge

Structural Basis

Long-acting analog of human amylin (IAPP), a 37-residue hormone co-secreted with insulin

Receptor Targets

Amylin receptors (AMYR) and the calcitonin receptor (CTR) — non-selective agonist

Also Known As

AM833, NNC0174-0833

Physical Form

Lyophilized white powder

Storage

36–46 °F (2–8 °C), desiccated and protected from light

Chemical Structure