AOD-9604

Description

AOD-9604 is a 16-amino-acid peptide with the sequence YLRIVQCRSVEGSCGF and a molecular weight of 1815.10 g/mol. It derives from the C-terminal region of human growth hormone.

What it is, precisely

AOD-9604 corresponds to residues 177 to 191 of human growth hormone with an additional tyrosine added at the N-terminus. It carries a disulfide bridge between the cysteines at positions 7 and 14, reproducing the loop structure that region forms in the parent hormone.

It is not the same as hGH Fragment 176-191. That unmodified fragment lacks the added tyrosine, carries a different registry number, and weighs 1799.10 g/mol, sixteen daltons less. The two are frequently conflated and sometimes substituted for one another in this market, but they are distinct compounds. The distinction also has a research history attached: AOD-9604 is the version that went through human clinical investigation, while the unmodified fragment did not, so literature describing clinical work refers specifically to the tyrosine-extended form.

If you are comparing published results or sourcing from multiple suppliers, confirm the registry number rather than the common name.

Why a fragment

Full-length growth hormone is a 191-residue protein with a broad activity profile, including effects on IGF-1 and glucose handling mediated through receptor binding. The C-terminal region was investigated on the premise that a short fragment might retain the lipolytic behaviour associated with the parent hormone while lacking the receptor interactions responsible for its other activities. Published work describes AOD-9604 as not significantly affecting IGF-1 levels or insulin sensitivity, which is the separation the design was intended to achieve.

Research background

Published work has examined the fragment in adipose tissue models in vitro and in rodent studies looking at lipid metabolism endpoints. The compound has been the subject of human clinical investigation.

No regulatory authority has approved AOD-9604 as a therapeutic. The material supplied here is for laboratory research only.

Storage and handling

Store the lyophilized powder at 36 to 46 °F (2 to 8 °C), desiccated and protected from light. Allow the vial to reach room temperature before opening.

The disulfide bridge is required for the correct loop conformation. Avoid reducing agents such as dithiothreitol or beta-mercaptoethanol, which will open the ring.

Use 1815.10 g/mol for molar calculations, and confirm you are not working from the 1799.10 figure for the unmodified fragment.

Purity and verification

Each lot is analysed by an independent laboratory, with identity confirmed by mass spectrometry and purity by HPLC. Test scope varies by lot; consult the certificate for the lot you receive.

Compound Identity

CAS Number

221231-10-3

Molecular Formula

C₇₈H₁₂₃N₂₃O₂₃S₂

Molecular Weight

1815.10 g/mol

PubChem CID

71300630

Chain Length

16 amino acids

Sequence

Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
YLRIVQCRSVEGSCGF

Disulfide Bond

Cys⁷–Cys¹⁴ bridge

Structural Basis

hGH residues 177–191 with an added N-terminal tyrosine

Not the Same As

Unmodified hGH Fragment 176–191 (CAS 66004-57-7, 1799.10 g/mol), which lacks the N-terminal Tyr

Also Known As

Tyr-hGH(177–191), AOD9604

Physical Form

Lyophilized white to off-white powder

Storage

36–46 °F (2–8 °C), desiccated and protected from light

Chemical Structure