5 AMINO 1MQ

Description

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase. It is supplied as the iodide salt, 5-amino-1-methylquinolinium iodide, with a molecular weight of 286.11 g/mol.

Not a peptide

Despite appearing in a peptide catalogue, this is a quaternary quinolinium compound: a fused bicyclic aromatic ring system carrying a permanent positive charge on a methylated nitrogen. It contains no amino acids and no peptide bonds, and the handling conventions used for peptides do not all transfer.

Salt form and why it matters for concentration calculations

The permanent positive charge on the quinolinium nitrogen means the compound cannot exist as a neutral free base. It is supplied as a salt, here the iodide.

This produces a calculation trap. The iodide salt weighs 286.11 g/mol, while the active cation alone weighs 159.21. Iodide therefore accounts for roughly 44 percent of the mass. Approximately 1.89 mg of the salt corresponds to 1 mg of the cation.

If a vial is labelled 50 mg, whether that means 50 mg of salt or 50 mg of cation changes the active content by nearly a factor of two. Confirm from your lot certificate which basis the stated content uses before calculating concentrations, and be aware that published literature may report quantities on either basis.

Mechanism

Nicotinamide N-methyltransferase methylates nicotinamide, consuming S-adenosyl methionine and diverting nicotinamide away from the NAD+ salvage pathway. Inhibiting the enzyme is investigated on the premise that less nicotinamide is diverted and more remains available for NAD+ synthesis.

This connects directly to NAD+, also in this catalogue: one is the cofactor itself, the other an inhibitor of an enzyme that competes for its precursor. The two are studied from opposite ends of the same pathway.

5-Amino-1MQ is described in published work as a substrate-site inhibitor, meaning it competes at the nicotinamide binding site rather than the cofactor site.

Research background

Published work has characterised enzyme inhibition in biochemical assays and examined the compound in adipocyte cultures and rodent models addressing metabolic endpoints. The literature is comparatively recent and smaller than for established compounds.

No regulatory authority has approved 5-Amino-1MQ for any use. The material supplied here is for laboratory research only.

Handling

Store at −4 °F (−20 °C), desiccated and protected from light. This is colder than the storage used for most peptides in this catalogue.

The powder is orange rather than white, which is normal for this compound and not an indication of degradation.

Use 286.11 g/mol for the iodide salt, or 159.21 for the cation, depending on which basis your work requires. State the basis explicitly in your records.

Store solutions cold and protected from light.

Purity and verification

Each lot is analysed by an independent laboratory. Test scope varies by lot; consult the certificate for the lot you receive.

Compound Identity

CAS Number

42464-96-0 (iodide salt)

Molecular Formula

C₁₀H₁₁N₂·I

Molecular Weight

286.11 g/mol (iodide salt)
Free cation C₁₀H₁₁N₂⁺ = 159.21 g/mol

Chemical Name

5-Amino-1-methylquinolinium iodide

Compound Class

Small-molecule quaternary quinolinium — not a peptide

Target

Nicotinamide N-methyltransferase (NNMT), substrate-site inhibitor

Salt Conversion

1.89 mg of the iodide salt corresponds to 1 mg of the free 5-amino-1MQ cation. Confirm which basis your lot is weighed on before calculating concentrations.

Physical Form

Orange powder

Storage

−4 °F (−20 °C), desiccated and protected from light

Chemical Structure